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Does Adrafinil Cause Liver Damage?

Adrafinil has quickly become one of the most popular nootropic supplements on the planet. Users are increasingly turning to this compound in order to help increase focus, boost motivation, and give them sustained energy throughout the day. However, Adrafinil does not come without a couple of side effects. One of the side effects that people worry about the most is the potential of elevated liver enzymes and liver damage. Let’s take a look at what exactly this compound is as well as the potential side effects that it can cause to the liver.

What is Adrafinil?

Before we get too far into this discussion, it’s important that we are all on the same page. Adrafinil was discovered by a French chemist a few decades ago. It was used in many countries throughout the world as a way to fight off narcolepsy in patients who fell asleep during the day. It has since been discontinued, and is now sold as a dietary supplement in countries such as the United States and Canada. Adrafinil converts to the prescription stimulant Modafinil inside the liver. This means that it has a lot of the same benefits and side effects as Modafinil.

Some of the most well-known benefits include increased energy and motivation. If you were to drink the typical cup of coffee, which has about 200 mg of caffeine, you would get a slight boost of energy that would quickly wear off within an hour or two. With Adrafinil, this energy typically last for 4 to 6 hours and as long as 8 to 10 hours in some people. For this reason, many users are finding that a great alternative to other stimulants. They can just take one capsule in the morning and feel a sustained boost of energy throughout the day.

How Does Adrafinil Work?

Once they start to hear about all of these benefits, a lot of people want to know how exactly Adrafinil works. Although the exact mechanism is not currently understood, this supplement works through a couple of different mechanisms within the human body. Once the liver converts Adrafinil to its active metabolites, it is distributed throughout the body and affects different functions. This conversion process takes place in the liver. Although the exact mechanism is too complex for this article to cover, just remember to ensure that your drinking adequate water to flush any toxins that can result from this process out of your body.

Adrafinil affects a couple of the main reward pathways in her brain. These include both dopamine and serotonin. You’ve probably heard of dopamine referred to as the happy chemical. When we do pleasurable activities such as eat delicious food, go on a date, or win the championship basketball game, dopamine is released into the body. This lets the brain know that it should be rewarding itself for a job well done. Adrafinil affects the dopamine receptors in order to help you feel good and receive a boost in mood. Serotonin is the chemical within the brain that regulates feelings. In addition, serotonin is one of the most important chemicals to make sure that our body is receiving adequate sleep.

Does Adrafinil Cause Liver Damage?

So, what you really want to know is does Adrafinil actually damage the liver? The short answer is no.

Once you swallow a capsule, the supplement travels through your body into the liver and is then broken down into several different components. This process is not unique to Adrafinil and is the same mechanism that Tylenol and other popular drugs are used to convert into something the body can actively use. The end result is the Adrafinil can lead to elevated liver enzymes in some people. This just means that your liver needs to work extra hard in order to convert the product into its active metabolites and then disperse them throughout the body.

Although this may seem unusual to some people, it is actually not that big of a deal. You’ve probably heard people talk about how Tylenol can damage the liver as well. This is extremely rare and only occurs of people take well above the recommended dosage over a long term. Adrafinil is the same way. It is suggested that people do not use it every day, and instead cycle its use. This gives the liver adequate time to cleanse itself and prepare for the next round of treatment.

The process of breaking Adrafinil down into the liver and then converting it into other ingredients is something that needs to be looked out over the long term instead of just over a day or two. Elevated liver enzymes are not going to occur after just taking Adrafinil a couple of times. Instead, they’re more likely to result if you use the supplement multiple times a day over a long period of time.

For this reason, it is suggested to follow a cycle dosage. Typically users will take 300 to 600 mg of Adrafinil on the day when they have not received enough sleep. This helps them to get the energy and focus they need to get through the day. As long as you’re only taking the supplement a couple of times a week, it is extremely unlikely that you will ever even notice a spike in liver enzymes. If you begin to use the product on a more consistent basis as in more than three times a week, make sure you check with your doctor to monitor your liver enzymes. Although it is very unlikely that permanent damage to the liver will occur, it’s important to work with your doctor to prevent these things before they even happen.

What Can I do to Protect My Liver?

If you are worried about Adrafinil damaging your liver, there are a couple of important steps that you can take to prevent this from happening. The first is stain adequately hydrated. Most people in the United States drink a lot of soda, coffee, and other sugary beverages. These type of drinks deprive the body of the hydration it needs to perform healthy body functions. You should aim to be drinking at least 1 gallon of water per day. Drinking this amount of water has a lot of health benefits including increasing your energy and helping you to get a better nights sleep. Drinking a lot of water also helps deliver to filter out any toxins that have might’ve developed throughout the day and expelled them through the urine.

The second thing that you can do to help protect your liver is to not combine Adrafinil with other things that will put a strain on the body. Drinking alcohol is a common activity that a lot of people participate in, but at the end of the day is very bad for you. Alcohol puts a strain on your liver and makes it difficult for your body to filter the toxins that you consume. It’s best if you minimize or cut out any alcohol that your drinking. As mentioned earlier in this article, Tylenol is also something that can cause liver problems if used over a consistent basis. For this reason, you should not combine Adrafinil with Tylenol or alcohol, in order to help your body keep functioning at a healthy level.

Other Side Effects

Although Adrafinil’s effects on the liver are some of the most commonly worried about side effects, there are a few other things that you should be on the lookout for. In rare cases the supplement can

lead to increased blood pressure and some people. Again, drinking water can help to mitigate this effect. The most common side effect that other people notice is a difficulty in falling asleep at night. This is because this nootropic supplement helps to increase energy and has a long period before it wears off. You should always try to dose your Adrafinil early in the morning in order to prevent the side effect from keeping you falling asleep at night.

Dosing Correctly

Before you start this or any other supplement regimen, it’s important they figure out a dosage that will work best for you. Everybody works a little bit differently, so you will need to monitor the effects that Adrafinil has on you to find the dosage that works best for you. Typically, user start out with one capsule which is 300 mg, early in the morning. The supplement can take about two hours to fully kick in, so make sure you wait at least that amount of time before you decide if you should take more. 300 mg is typically the sweet spot between benefits and side effects for a lot of people. However some users up the dosage to two or three capsules per day in order to feel its full effects.

You should never take more than three capsules in any given day, because the benefits do not increase but the side effects increase exponentially. Make sure you cycle the product and do not use it more than a few times every week.

Although a lot of website so powder, this makes it a lot more difficult to dose your Adrafinil effectively. We recommend always using capsules that have been manufactured in a GMP authorized facility. This means that the highest quality standards will have been used to ensure that your supplement is accurately dosed. This is truly the only way that you can tell if you’re getting an accurate dosage.

User Experiences and Reviews

The experience that you have with Adrafinil will probably differ from some of the reviews that you’ve read online. This is because everybody reacts a little bit differently to the product. We have collected a lot of the user experiences that people have while using our Adrafinil products. We are working on compiling the list of reviews that people have and will be posting them online soon. If you have a review that you would like to share, please reach out to us and we would love to hear from you.


All in all, Adrafinil is a very safe supplement to use. It can cause elevated liver enzymes and some people, but this can greatly be mitigated by following a couple of safe procedures. First, make sure you are drinking at least 1 gallon of water per day. This will help your body to cleanse itself of any toxins. Second, make sure that you are cycling the supplement. This means that you should never be taking more than the recommended dosage of Adrafinil and only taking a few days a week at most. If you follow these simple procedures, you will give your body a fighting chance to keep your liver healthy so you can keep using Adrafinil for a very long time.

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